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纺锤体和着丝粒相关蛋白2抗体
产物名称 | 英文名称 | 货号 |
纺锤体和着丝粒相关蛋白2抗体 | SKA2 | GOY-01K2180 |
商品属性：
英文名称: SKA2
中文名:纺锤体和着丝粒相关蛋白2抗体
别 名；FAM33A; Family
with sequence similarity 33, member A; FLJ12758; MGC110975; Protein FAM33A; SKA
2; SKA2; SKA2_HUMAN; Spindle and kinetochore associated complex subunit 2;
Spindle and kinetochore associated protein 2; Spindle and
kinetochore-associated protein 2; Spindle and KT (kinetochore) associated 2;
Spindle and KT associated 2.
研究领域；细胞生物 细胞周期蛋白 细胞分化
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
产物应用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；14kDa
细胞定位；细胞核 细胞浆
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human SKA2: 2-88/121
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M TBS(pH7.4)
with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
Ska2 (spindle and kinetochore associated complex
subunit 2), also known as FAM33A, is a 121 amino acid component of the Ska1
complex, a microtubule-binding subcomplex of the outer kinetochore that is
critical for proper chromosome segregation. The Ska1 complex is a component
of the kinetochore-microtubule interface and directly associates with
microtubules as oligomeric assemblies. Localized to the outer kinetochore and
spindle microtubules during cell proliferation, Ska2 is essential for spindle
checkpoint silencing and exit from mitosis. Downregulation of Ska2 leads to
delayed recruitment of MAD2, a component of the mitotic spindle checkpoint,
to several kinetochores resulting in occasional loss of individual
chromosomes from the metaphase plate. Ska2 is encoded by a gene located on
human chromosome 17, which comprises over 2.5% of the human genome and
encodes over 1,200 genes. Component of the SKA1 complex, a
microtubule-bindingsubcomplex of the outer kinetochore that is essential for
properchromosome segregation. Required for timely anaphase onset
duringmitosis, when chromosomes undergo bipolar attachment on
spindlemicrotubules leading to silencing of the spindle checkpoint. TheSKA1
complex is a direct component of the kinetochore-microtubuleinterface and
directly associates with microtubules as oligomericassemblies. The complex
facilitates the processive movement ofmicrospheres along a microtubule in a
depolymerization-coupledmanner. In the complex, it is required for SKA1
localization. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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